General Information of Drug (ID: DMG75P3)

Drug Name
4SC-205 Drug Info
Indication
Disease Entry ICD 11 Status REF
Lymphoma 2A80-2A86 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMG75P3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AZD-4877 DMFVL5J Acute myeloid leukaemia 2A60 Phase 2 [2]
ARRY-520 DMTOI7S Multiple myeloma 2A83 Phase 2 [3]
Ispinesib DMP2BWX Head and neck cancer 2D42 Phase 2 [4]
SB-743921 DM6XJ9S Solid tumour/cancer 2A00-2F9Z Phase 2 [5]
LY2523355 DMCV602 Acute myeloid leukaemia 2A60 Phase 2 [2]
ARQ 621 DMCRLQZ Haematological malignancy 2B33.Y Phase 1 [2]
MK-0731 DM2TAUR Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
Monastrol DMLSEJN Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Kinesin-like protein KIF11 (KIF11) TTTRP0H KIF11_HUMAN Inhibitor [1]

References

1 2011 Pipeline of 4SC AG.
2 Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39.
3 Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells. Leukemia. 2009 Oct;23(10):1755-62.
4 Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program. Pediatr Blood Cancer. 2009 Dec 15;53(7):1255-63.
5 Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Jan-Feb;31(1):47-57.
6 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.