Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG8NLI)

Drug Name

P-9808 Drug Info

Synonyms

Porphogen; Porphozym; PBGD, HemeBiotech; PBGD, Zymenex; Recombinant porphobilinogen deaminase, HemeBiotech; Recombinant porphobilinogen deaminase, Zymenex

Indication

Disease Entry	ICD 11	Status	REF
Porphyria	5C58.1	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMG8NLI

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Porphobilinogen deaminase (HMBS)	TTT0HW3	HEM3_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT00418795) Porphozym in the Treatment of Acute Attacks in AIP. U.S. National Institutes of Health.
2	Safety, pharmacokinetics and pharmocodynamics of recombinant human porphobilinogen deaminase in healthy subjects and asymptomatic carriers of the acute intermittent porphyria gene who have increased porphyrin precursor excretion. Clin Pharmacokinet. 2007;46(4):335-49.