Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGD1YP)

Drug Name

MEDI9929 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Thymic stromal lymphopoietin (TSLP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tezepelumab	DM9R5J6	Severe asthma	CA23	Approved	[3]
A378	DMUWRTB	Asthma	CA23	IND submitted	[4]
CSJ117	DMZJUV6	Asthma	CA23	Phase 2	[5]
AMG 104	DM3XC31	Asthma	CA23	Phase 1	[6]
AZD8630	DMMUF0O	Asthma	CA23	Phase 1	[7]
PF-07275315	DMHRVUY	Atopic dermatitis	EA80	Phase 1	[8]
SAR443765	DMLYI4Z	Asthma	CA23	Phase 1	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thymic stromal lymphopoietin (TSLP)	TTHMW3T	TSLP_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT02054130) Study to Evaluate the Efficacy and Safety of MEDI9929 (AMG 157) in Adult Subjects With Inadequately Controlled, Severe Asthma. U.S. National Institutes of Health.
2	Human immunoglobulin G2Lambda monoclonal antibody directed against thymic stromal lymphopoietin (MEDI9929). European medicines agency science medicines health (EMEA-001613-PIP01-14). European Union. 2015.
3	Tezepelumab in Adults with Uncontrolled Asthma. N Engl J Med. 2017 Sep 7;377(10):936-946.
4	Clinical pipeline report, company report or official report of Klus Pharma
5	TSLP Inhibitors for Asthma: Current Status and Future Prospects. Drugs. 2020 Apr;80(5):449-458.
6	Clinical pipeline report, company report or official report of Amgen
7	Clinical pipeline report, company report or official report of AstraZeneca
8	Clinical pipeline report, company report or official report of Pfizer
9	Clinical pipeline report, company report or official report of Sanofi