Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGGJAR)

Drug Name

QR-421a Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Retinitis pigmentosa	9B70	Phase 2/3	[1]

Cross-matching ID

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Usherin messenger RNA (USH2A mRNA)	TTVCLLA	USH2A_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT05176717) A Double-Masked, Randomized, Controlled, Multiple-Dose Study to Evaluate the Efficacy, Safety and Tolerability of QR-421a in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene With Early to Moderate Vision Loss. U.S.National Institutes of Health.
2	Antisense oligonucleotide-based treatment of retinitis pigmentosa caused by USH2A exon 13 mutations. Mol Ther. 2021 Aug 4;29(8):2441-2455.