Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGH1LX)

Drug Name

BMS-509744 Drug Info

Synonyms

BMS-509744; 439575-02-7; BMS 509744; CHEMBL209148; N-(5-((5-(4-Acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl)thio)thiazol-2-yl)-4-(((3,3-dimethylbutan-2-yl)amino)methyl)benzamide; N-[5-[5-(4-acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl]sulfanyl-1,3-thiazol-2-yl]-4-[(3,3-dimethylbutan-2-ylamino)methyl]benzamide; GTPL9994; SCHEMBL14460651; KS-00001CVA; CHEBI:91404; MolPort-039-101-283; C32H41N5O4S2; BMS509744; BDBM50186460; 3499AH; compound 3 [PMID:16682193]; AKOS025142036; NCGC00229512-02; NCGC00229512-01

Indication

Disease Entry	ICD 11	Status	REF
Inflammation	1A00-CA43.1	Investigative	[1]

Cross-matching ID

PubChem CID: 11467730
ChEBI ID: CHEBI:91404
CAS Number: CAS 439575-02-7
TTD Drug ID: DMGH1LX

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting T-cell-specific kinase (ITK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
JTE-051	DM2LBHN	Plaque psoriasis	EA90.0	Phase 2	[2]
CPI-818	DMMBQ20	T-cell lymphoma	2A90	Phase 1	[3]
Pyrazolo[4,3-c]pyridine derivative 2	DMCDFLQ	N. A.	N. A.	Patented	[4]
PMID27774824-Compound-Figure3Example7	DMXDOGK	N. A.	N. A.	Patented	[4]
BMS-488516	DM6Y1QF	Inflammation	1A00-CA43.1	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
T-cell-specific kinase (ITK)	TT3C80U	ITK_HUMAN	Inhibitor	[1]

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References

1	Treatment of depersonalization with serotonin reuptake blockers. J Clin Psychopharmacol. 1990 Jun;10(3):200-3.
2	Characterisation of a K390R ITK Kinase Dead Transgenic Mouse - Implications for ITK as a Therapeutic Target. PLoS One. 2014; 9(9): e107490.
3	Clinical pipeline report, company report or official report of Corvus Pharmaceuticals.
4	Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143.