Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGJIR8)

Drug Name

KB105 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Autosomal Recessive Ichthyosis	ED20	Phase 2	[1]

Cross-matching ID

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Protein-glutamine gamma-glutamyltransferase K (TGM1)	TT7A949	TGM1_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT05735158) A Phase 2, Randomized, Placebo-controlled Study of Topical KB105, a Replication-defective, Non-integrating HSV-1 Vector Expressing Human Transglutaminase 1 (TGM1) for the Treatment of TGM1-deficient Autosomal Recessive Congenital Ichthyosis (ARCI). U.S.National Institutes of Health.
2	Preclinical Evaluation of a Modified Herpes Simplex Virus Type 1 Vector Encoding Human TGM1 for the Treatment of Autosomal Recessive Congenital Ichthyosis. J Invest Dermatol. 2021 Apr;141(4):874-882.e6.