Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGN051)

Drug Name

ISIS 6443 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting PKC-eta messenger RNA (PRKCH mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[2]
LY-326449	DMN53M4	Discovery agent	N.A.	Investigative	[3]
PROSTRATIN	DM1HMJ5	Human immunodeficiency virus infection	1C62	Investigative	[4]
8-Octyl-benzolactam-V9	DM4Z15M	Discovery agent	N.A.	Investigative	[5]
ISIS 6445	DMXJ4SO	Discovery agent	N.A.	Investigative	[1]
ISIS 6432	DMQHN43	Discovery agent	N.A.	Investigative	[1]
ISIS 6553	DM5L387	Discovery agent	N.A.	Investigative	[1]
ISIS 6581	DMEAVPQ	Discovery agent	N.A.	Investigative	[1]
ISIS 6442	DM7KSRG	Discovery agent	N.A.	Investigative	[1]
ISIS 6434	DMNVLE2	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PKC-eta messenger RNA (PRKCH mRNA)	TTONI0R	KPCL_HUMAN	Not Available	[1]

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References

1	US patent application no. 5,959,096, Antisense oligonucleotides against human protein kinase C.
2	Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins, Bioorg. Med. Chem. Lett. 5(18):2155-2160 (1995).
3	(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71.
4	A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86.
5	Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. J Med Chem. 2006 May 4;49(9):2681-8.