General Information of Drug (ID: DMGRWA3)

Drug Name
ANHYDRORYANIDINE Drug Info
Synonyms
anhydroryanidine; CHEMBL283783; BDBM50044991; 2,6,9,11,13,14-hexahydroxy-11-isopropyl-7,10-dimethyl-3-methylene-(2R,7S,12R)-15-oxapentacyclo[7.5.1.01,6.07,13.010,14]pentadec-12-yl 1H-2-pyrrolecarboxylate(Dehydroryanodine); 2,6,9,11,13,14-hexahydroxy-11-isopropyl-7,10-dimethyl-3-methylene-(1R,7S,9S,12R)-15-oxapentacyclo[7.5.1.01,6.07,13.010,14]pentadec-12-yl 1H-2-pyrrolecarboxylate
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44275813
TTD Drug ID
DMGRWA3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Discontinued Drug(s)
Investigative Drug(s)
Drug(s) Targeting Ryanodine receptor 1 (RYR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ARM036 DMNGQM0 Heart failure BD10-BD13 Discontinued in Phase 2 [2]
CDP-1050 DM5BG4P Heart failure BD10-BD13 Discontinued in Phase 1 [2]
Benzyloxycarbonyl-glycylryanodine DMLJMOD Discovery agent N.A. Investigative [1]
Ruthenium red DMOHTC6 Discovery agent N.A. Investigative [3]
(O10eq)-beta-alanyl-anhydro-ryanodine DMRSZGB Discovery agent N.A. Investigative [1]
GLYCYLRYANODINE DMTOCXZ Discovery agent N.A. Investigative [1]
N-methyl ryanodine-succinamidate DMXGY4F Discovery agent N.A. Investigative [1]
Ryanodine DM2K6I8 Discovery agent N.A. Investigative [4]
Di-Benzyloxycarbonyl-guanidino acetylryanodine DMAYSGI Discovery agent N.A. Investigative [1]
(O10eq)-beta-guanidinopropionylryanodine DMSV8XM Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ryanodine receptor 1 (RYR1) TTU5CIX RYR1_HUMAN Inhibitor [1]

References

1 Amino- and guanidinoacylryanodines: basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca(2+)-release channel. J Med Chem. 1993 May 14;36(10):1319-23.
2 The Ryanodine Receptor Stabilizer S44121 / Arm036 Improves Peripheral and Respiratory Muscle Function in a Mouse Model of Heart Failure. Circulation. 2014; 130: A13726.
3 Role of ryanodine receptor channels in Ca2+ oscillations of porcine tracheal smooth muscle. Am J Physiol. 1997 Apr;272(4 Pt 1):L659-64.
4 The contribution of inositol 1,4,5-trisphosphate and ryanodine receptors to agonist-induced Ca(2+) signaling of airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L347-61.