Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGTAWC)

Drug Name
RKI-1447 Drug Info
Synonyms RKI1447; compound 5g [PMID 23275831]
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
60138149
TTD Drug ID
DMGTAWC

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Rho-associated protein kinase 2 (ROCK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Belumosudil DM548TK Graft-versus-host disease 4B24 Approved [2]
INS-117548 DMA46DO Glaucoma/ocular hypertension 9C61 Phase 1 [3]
GSK269962A DM5I2HL Inflammation 1A00-CA43.1 Clinical trial [4]
PMID28048944-Compound-19 DMPT3V9 N. A. N. A. Patented [5]
PMID28048944-Compound-3 DM1BN74 N. A. N. A. Patented [5]
PMID28048944-Compound-7 DMXZ368 N. A. N. A. Patented [5]
PMID28048944-Compound-4 DMJAUWG N. A. N. A. Patented [5]
PMID28048944-Compound-5 DMAB987 N. A. N. A. Patented [5]
PMID28048944-Compound-6 DM5RCBV N. A. N. A. Patented [5]
PMID28048944-Compound-2 DM9ZXOP N. A. N. A. Patented [5]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting PAK-1 protein kinase (PAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID20005102C1 DMMESBW Discovery agent N.A. Investigative [6]
Il-94 DMPNQ27 Discovery agent N.A. Investigative [7]
Drug(s) Targeting Rho-associated protein kinase 1 (ROCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Netarsudil DM0LPI9 Open-angle glaucoma 9C61 Approved [8]
SAR-407899 DMF95KD Diabetic nephropathy GB61.Z Phase 2 [9]
H-1152 DM8XH3S Pulmonary arterial hypertension BB01.0 Phase 2 [10]
INS-117548 DMA46DO Glaucoma/ocular hypertension 9C61 Phase 1 [3]
GSK269962A DM5I2HL Inflammation 1A00-CA43.1 Clinical trial [4]
PMID28048944-Compound-19 DMPT3V9 N. A. N. A. Patented [5]
PMID28048944-Compound-3 DM1BN74 N. A. N. A. Patented [5]
PMID28048944-Compound-7 DMXZ368 N. A. N. A. Patented [5]
PMID28048944-Compound-4 DMJAUWG N. A. N. A. Patented [5]
PMID28048944-Compound-5 DMAB987 N. A. N. A. Patented [5]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Protein kinase N1 (PKN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID22136433C20 DMI8217 Discovery agent N.A. Investigative [11]
Drug(s) Targeting DMPK messenger RNA (DMPK mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS-DMPK DMH32LC Myotonic dystrophy 8C71.0 Phase 1/2 [12]
PRO-135 DMA2SBL Myotonic dystrophy 8C71.0 Investigative [13]
2-MOE phosphorothioate gapmers DM4IJXW Myotonic dystrophy 8C71.0 Investigative [13]
Drug(s) Targeting LIM domain kinase-1 (LIMK-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID22902653C30 DMXDTPL Discovery agent N.A. Investigative [14]
PMID22902653C31 DMWVTAE Discovery agent N.A. Investigative [14]
PMID22902653C35 DMLVKPG Discovery agent N.A. Investigative [14]
PMID19831390C14 DMIECOF Discovery agent N.A. Investigative [15]
Drug(s) Targeting Myosin light kinase (MYLK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ME-3407 DMO84TL Duodenal ulcer DA63 Phase 2 [16]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
CDC42 binding protein kinase alpha (DMPK-like alpha) TT5Z0EF MRCKA_HUMAN Inhibitor [1]
DMPK messenger RNA (DMPK mRNA) TTZQTY2 DMPK_HUMAN Inhibitor [1]
LIM domain kinase-1 (LIMK-1) TTWL9TY LIMK1_HUMAN Inhibitor [1]
Myosin light kinase (MYLK) TT18ETS MYLK_HUMAN Inhibitor [1]
PAK-1 protein kinase (PAK1) TTFN95D PAK1_HUMAN Inhibitor [1]
Protein kinase N1 (PKN1) TTSL41O PKN1_HUMAN Inhibitor [1]
Rho-associated protein kinase 1 (ROCK1) TTZN7RP ROCK1_HUMAN Inhibitor [1]
Rho-associated protein kinase 2 (ROCK2) TTGWKQJ ROCK2_HUMAN Inhibitor [1]

References

1 Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709.
2 Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16814-9.
3 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
4 Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98.
5 Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515.
6 2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles. Bioorg Med Chem Lett. 2010 Jan 15;20(2):679-83.
7 PAK1: A Therapeutic Target for Cancer Treatment. ACS Med Chem Lett. 2013 Mar 19;4(5):431-2.
8 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
9 The Rho kinase inhibitor SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries. J Hypertens. 2012 May;30(5):980-9.
10 Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19.
11 7,8-dichloro-1-oxo-beta-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. J Med Chem. 2012 Jan 12;55(1):403-13.
12 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.
13 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1505).
14 Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8.
15 Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem. 2009 Nov 12;52(21):6515-8.
16 ME-3407, a new antiulcer agent, inhibits acid secretion by interfering with redistribution of H(+)-K(+)-ATPase. Am J Physiol. 1997 May;272(5 Pt 1):G1122-34.