Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGW07M)

Drug Name
Aloxistatin Drug Info
Synonyms
NSC694281; AC1L95AQ; SCHEMBL254426; CHEMBL1978255; CTK8C9289; ethyl(2s,3s)-3-[[1-(isopentylcarbamoyl)-3-methyl-butyl]carbamoyl]oxirane-2-carboxylate; NSC-694281; VC30685; NCI60_033765; ethyl (2S,3S)-3-[[4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylate; 2-Oxiranecarboxylicacid,3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-,ethyl ester, (2S,3S)-
Indication
Disease Entry ICD 11 Status REF
Neurological disorder 6B60 Discontinued in Phase 3 [1]
Coronavirus infection 1D92 Preclinical [2]
Cross-matching ID
PubChem CID
65663
ChEBI ID
CHEBI:101381
CAS Number
CAS 88321-09-9
TTD Drug ID
DMGW07M

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Calpain-2 (CAPN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ABT-957 DMB9N4J Alzheimer disease 8A20 Phase 1 [5]
PMID25399719-Compound-17 DMRXKJZ N. A. N. A. Patented [6]
Epoxysuccinate derivative 9 DM49FU0 N. A. N. A. Patented [6]
Epoxysuccinate derivative 4 DMCF6M8 N. A. N. A. Patented [6]
Carboxamide derivative 7 DM8TQS4 N. A. N. A. Patented [6]
Epoxysuccinate derivative 7 DMTSPVF N. A. N. A. Patented [6]
Carboxamide derivative 10 DM5WMO9 N. A. N. A. Patented [6]
Carboxamide derivative 11 DM1DN94 N. A. N. A. Patented [6]
Carboxamide derivative 8 DM6HI34 N. A. N. A. Patented [6]
Epoxysuccinate derivative 10 DMYF39U N. A. N. A. Patented [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Cathepsin G (CTSG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
JNJ-10311795 DM7OTQS Chronic obstructive pulmonary disease CA22 Phase 2 [7]
Peptide analog 59 DMZAMNX N. A. N. A. Patented [8]
Peptide analog 61 DM45JMT N. A. N. A. Patented [8]
Peptide analog 55 DMVLP8H N. A. N. A. Patented [8]
Peptide analog 60 DMMSTNA N. A. N. A. Patented [8]
Peptide analog 70 DMN43Q5 N. A. N. A. Patented [8]
Peptide analog 56 DMBCFJU N. A. N. A. Patented [8]
Peptide analog 57 DM6IQWE N. A. N. A. Patented [8]
Peptide analog 58 DM7X62M N. A. N. A. Patented [8]
Peptide analog 62 DM28NK0 N. A. N. A. Patented [8]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Calpain-2 (CAPN2) TTG5QB7 CAN2_HUMAN Inhibitor [3]
Cathepsin G (CTSG) TTQAJF1 CATG_HUMAN Inhibitor [4]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002441)
2 Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
3 In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
4 Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem. 2007 Jul 20;282(29):20836-46.
5 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
6 An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31.
7 Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J Med Chem. 2007 Apr 19;50(8):1727-30.
8 Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58.