Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGWZA3)

Drug Name

PMID25974391C34 Drug Info

Synonyms

GTPL8396; BDBM50148478; AKOS004992742; MCULE-8876093508; J3.601.438E; 4QH

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Bromodomain and PHD finger containing 1 (BRPF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NI-57	DM52ITO	Discovery agent	N.A.	Investigative	[2]
PMID25408830C3	DM8SBR2	Discovery agent	N.A.	Investigative	[3]
OF-1	DMK8LEC	Discovery agent	N.A.	Investigative	[2]
PMID25408830C1	DM5GL23	Discovery agent	N.A.	Investigative	[3]
PMID25408830C2	DM20E13	Discovery agent	N.A.	Investigative	[3]
PFI-4	DMPKXNZ	Discovery agent	N.A.	Investigative	[2]
------------------------------------------------------------------------------------


⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bromodomain and PHD finger containing 1 (BRPF1)	TTT46BN	BRPF1_HUMAN	Inhibitor	[1]
Tripartite motif-containing 24 (TRIM24)	TT9Q7AE	TIF1A_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF. J Med Chem. 2016 Feb 25;59(4):1642-7.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2730).
3	1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain. ACS Med Chem Lett. 2014 Sep 10;5(11):1190-5.