Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMH32LC)

Drug Name

ISIS-DMPK Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Myotonic dystrophy	8C71.0	Phase 1/2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting DMPK messenger RNA (DMPK mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RKI-1447	DMGTAWC	Discovery agent	N.A.	Investigative	[3]
PRO-135	DMA2SBL	Myotonic dystrophy	8C71.0	Investigative	[4]
2-MOE phosphorothioate gapmers	DM4IJXW	Myotonic dystrophy	8C71.0	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

References

1	ClinicalTrials.gov (NCT02312011) A Safety andTolerability Study of Multiple Doses of ISIS-DMPKRx in Adults With Myotonic Dystrophy Type 1. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.
3	Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1505).