Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMH4MBW)

Drug Name

ET bromodomain inhibitor Drug Info

Synonyms

Methyl (2r)-2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]butanoate; ET bromodomain inhibitor; GTPL7808; SCHEMBL16771873

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 86277843
TTD Drug ID: DMH4MBW

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Bromodomain-containing protein 2 (BRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[2]
ABBV-744	DMTEA9C	Acute myeloid leukaemia	2A60	Phase 1	[3]
PMID26924192-Compound-104	DM346EU	N. A.	N. A.	Patented	[4]
PMID26924192-Compound-102	DMEJ107	N. A.	N. A.	Patented	[4]
PMID26924192-Compound-103	DMWOCP7	N. A.	N. A.	Patented	[4]
PMID26924192-Compound-105	DMAWLGI	N. A.	N. A.	Patented	[4]
Pyrrolo-pyrrolone derivative 1	DMN4SE5	N. A.	N. A.	Patented	[4]
PMID26924192-Compound-106	DM9HRZJ	N. A.	N. A.	Patented	[4]
XD14	DMUMACD	Discovery agent	N.A.	Investigative	[5]
GW841819X	DMRL9IN	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bromodomain-containing protein 2 (BRD2)	TTDP48B	BRD2_HUMAN	Inhibitor	[1]

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References

1	Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes. Science. 2014 Oct 31;346(6209):638-41.
2	Targeting bromodomains: epigenetic readers of lysine acetylation.Nat Rev Drug Discov.2014 May;13(5):337-56.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22.
5	4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14055-9.
6	Discovery and characterization of small molecule inhibitors of the BET family bromodomains. J Med Chem. 2011 Jun 9;54(11):3827-38.