Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMH4TY1)

Drug Name
Tricyclic isoxazoloquinazoline derivative 2 Drug Info
Synonyms PMID27646439-Compound-12
Cross-matching ID
PubChem CID
66713957
TTD Drug ID
DMH4TY1

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting PRKR-like endoplasmic reticulum kinase (PERK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
HC-5404 DMKFZW5 Breast cancer 2C60-2C65 Phase 1 [2]
Tricyclic isoxazoloquinazoline derivative 4 DM8VIM4 N. A. N. A. Patented [1]
Tricyclic isoxazoloquinazoline derivative 3 DML2PWF N. A. N. A. Patented [1]
Phenylpyrrolidinone derivative 3 DMPZKQN N. A. N. A. Patented [1]
Indoline derivative 6 DMU5KWC N. A. N. A. Patented [1]
Tricyclic isoxazoloquinazoline derivative 1 DM6QSND N. A. N. A. Patented [1]
Phenylpyrrolidinone derivative 1 DMPAI5C N. A. N. A. Patented [1]
Phenylpyrrolidinone derivative 5 DMZSTLH N. A. N. A. Patented [1]
Indoline derivative 3 DM20YBJ N. A. N. A. Patented [1]
Indoline derivative 11 DM6JR3X N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Dual specificity protein kinase TTK (MPS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BOS172722 DMU790L Solid tumour/cancer 2A00-2F9Z Phase 1 [3]
BAY1161909 DMUK6YM Solid tumour/cancer 2A00-2F9Z Phase 1 [4]
CFI-402257 DMH701Q Solid tumour/cancer 2A00-2F9Z Phase 1 [5]
Tricyclic isoxazoloquinazoline derivative 4 DM8VIM4 N. A. N. A. Patented [1]
Tricyclic isoxazoloquinazoline derivative 3 DML2PWF N. A. N. A. Patented [1]
2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One DMDN12L Discovery agent N.A. Investigative [6]
GNE-7915 DMYWM56 Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dual specificity protein kinase TTK (MPS1) TTP7EGM TTK_HUMAN Inhibitor [1]
PRKR-like endoplasmic reticulum kinase (PERK) TT5OU0D E2AK3_HUMAN Inhibitor [1]

References

1 Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48.
2 Clinical pipeline report, company report or official report of HiberCell
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 National Cancer Institute Drug Dictionary (drug id 761238).
5 Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3127-3132.
6 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
7 Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2014 Feb 13;57(3):921-36.