Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMH5CAL)

Drug Name
ARQ 761 Drug Info
Indication
Disease Entry ICD 11 Status REF
Pancreatic cancer 2C10 Phase 2 [1]
Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
Cross-matching ID
TTD Drug ID
DMH5CAL

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Quinone reductase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Coenzyme Q10 analog DMO0VGH Huntington disease 8A01.10 Phase 2 [3]
BioE-743 DM7PT8R Leigh syndrome 5C53.24 Phase 2 [4]
Flavin-Adenine Dinucleotide DM5S4GK Discovery agent N.A. Investigative [5]
NSC-645808 DMMBAR3 Discovery agent N.A. Investigative [6]
NSC-106080 DMR6P9S Discovery agent N.A. Investigative [7]
NSC-99528 DMXZAIG Discovery agent N.A. Investigative [7]
NSC-354279 DMVL51I Discovery agent N.A. Investigative [6]
Duroquinone DML7YPS Discovery agent N.A. Investigative [5]
Ethyl Bis(4-hydroxy-2-oxo-2H-chromen-3-yl)acetate DMJQTIK Discovery agent N.A. Investigative [8]
3-Benzyl-4-hydroxy-2H-benzo[h]chromen-2-one DMA5EHC Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Quinone reductase 1 (NQO1) TT8XK6L NQO1_HUMAN Inhibitor [1]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020571)
3 Therapeutic strategies for Leber's hereditary optic neuropathy: A current update. Intractable Rare Dis Res. 2013 November; 2(4): 130-135.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
6 In silico identification and biochemical characterization of novel inhibitors of NQO1. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6246-54.
7 In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
8 Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem. 2009 Nov 26;52(22):7142-56.