General Information of Drug (ID: DMH5LKS)

Drug Name
CPA-926 Drug Info
Synonyms 6-(2-Acetamido-2-deoxy-beta-D-glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one
Indication
Disease Entry ICD 11 Status REF
Arthritis FA20 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
9800054
TTD Drug ID
DMH5LKS

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug(s) Targeting Lipoxygenase (ALOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TZI-41078 DMKJIDU Arthritis FA20 Phase 2 [3]
FLM-5011 DMKWTPX Inflammation 1A00-CA43.1 Discontinued in Phase 1 [4]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Lipoxygenase (ALOX) TTG3K2U NOUNIPROTAC Modulator [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018063)
2 Esculetin (dihydroxycoumarin) inhibits the production of matrix metalloproteinases in cartilage explants, and oral administration of its prodrug, CPA-926, suppresses cartilage destruction in rabbit experimental osteoarthritis. J Rheumatol. 1999 Mar;26(3):654-62.
3 Hydroxylamine analogs of 2,6-di-t-butylphenols: dual inhibitors of cyclooxygenase and 5-lipoxygenase or selective 5-lipoxygenase inhibitors. Bioorg Med Chem. 1995 Apr;3(4):403-10.
4 Lipoxygenase inhibitor FLM 5011, an effective protectant of myocardial microvessels against ischemia-reperfusion injury. Exp Toxicol Pathol. 2000 Mar;52(1):27-36.