Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMH9GWW)

Drug Name
DSG3-CAART Drug Info
Indication
Disease Entry ICD 11 Status REF
Pemphigus vulgaris EB40 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMH9GWW

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Desmoglein-3 (DSG3) TTEO4P8 DSG3_HUMAN Not Available [2]

References

1 ClinicalTrials.gov (NCT04422912) A Phase 1, Open-label, Safety and Dosing Study of Autologous Desmoglein 3 Chimeric Autoantibody Receptor T Cells (DSG3-CAART) in Subjects With Active, Anti-DSG3, Mucosal-dominant Pemphigus Vulgaris. U.S.National Institutes of Health.
2 Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris. J Clin Invest. 2020 Dec 1;130(12):6317-6324.