Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHATCZ)

Drug Name

Tpl2 kinase inhibitor Drug Info

Synonyms

Tpl2 Kinase Inhibitor; 871307-18-5; 4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile; CHEMBL200381; 4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-[(3-PYRIDINYLMETHYL)AMINO]-1,7-NAPHTHYRIDINE-3-CARBONITRILE; 4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine; K00599a; 4-[(3-chloro-4-fluorophenyl)amino]-6-[(pyridin-3-ylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9549300
CAS Number: CAS 871307-18-5
TTD Drug ID: DMHATCZ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Cot oncogene messenger RNA (MAP3K8 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
8-chloro-quinoline-3-carbonitrile	DMFNUHQ	Discovery agent	N.A.	Investigative	[3]
NSC-686549	DM0164B	Discovery agent	N.A.	Investigative	[4]
ISIS 116361	DMWBQHS	Discovery agent	N.A.	Investigative	[5]
ISIS 116414	DM4Q3JO	Discovery agent	N.A.	Investigative	[5]
ISIS 116360	DMFEZHM	Discovery agent	N.A.	Investigative	[5]
ISIS 116359	DM280AE	Discovery agent	N.A.	Investigative	[5]
ISIS 116362	DM7M1UB	Discovery agent	N.A.	Investigative	[5]
ISIS 116363	DMXKAJP	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cot oncogene messenger RNA (MAP3K8 mRNA)	TTGECUM	M3K8_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6051).
2	Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5288-92.
3	Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. J Biol Chem. 2007 Nov 16;282(46):33295-304.
4	A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8.
5	US patent application no. 6,265,216, Antisense modulation of cot oncogene expression.