Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHD8UL)

Drug Name

PD-151307 Drug Info

Synonyms

PD-151307; CHEMBL135329; BDBM50076106; Benzoic acid 4-((S)-2-{(S)-2-[(azepane-1-carbonyl)-amino]-4-methyl-pentanoylamino}-2-tert-butoxycarbonyl-ethyl)-phenyl ester; (S)-2-[[(S)-2-(Hexahydro-1H-azepine-1-ylcarbonylamino)-4-methylpentanoyl]amino]-3-[4-(benzoyloxy)phenyl]propionic acid tert-butyl ester

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 44356037
TTD Drug ID: DMHD8UL

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Preclinical Drug(s)

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Drug(s) Targeting Voltage-gated calcium channel alpha Cav2.2 (CACNA1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LOMERIZINE	DME0TC8	Migraine	8A80	Approved	[2]
Ziconotide	DMSLJP4	Pain	MG30-MG3Z	Approved	[3]
Hesperidin	DMI5DW1	Vascular purpura	3B60	Approved	[4]
Cilnidipine	DM1975O	High blood pressure	BA00	Phase 3	[5]
Ralfinamide	DMUNMY0	Neuropathic pain	8E43.0	Phase 3	[6]
CNV-2197944	DMLT7JV	Pain	MG30-MG3Z	Phase 2	[7]
Ritanserin	DM0X36Y	Anxiety disorder	6B00-6B0Z	Discontinued in Phase 3	[8]
CNSB-004	DMHAI0M	Pain	MG30-MG3Z	Preclinical	[9]
TH-9229	DMG1MPD	Reperfusion injury	ND56.Z	Terminated	[10]
PD-157667	DM61NFD	N. A.	N. A.	Terminated	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated calcium channel alpha Cav2.2 (CACNA1B)	TT4FDG6	CAC1B_HUMAN	Inhibitor	[1]

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References

1	Synthesis of a series of 4-benzyloxyaniline analogues as neuronal N-type calcium channel blockers with improved anticonvulsant and analgesic proper... J Med Chem. 1999 Oct 7;42(20):4239-49.
2	Synthesis and SAR of novel 2-arylthiazolidinones as selective analgesic N-type calcium channel blockers. Bioorg Med Chem Lett. 2007 Feb 1;17(3):662-7.
3	Emerging treatments for traumatic brain injury. Expert Opin Emerg Drugs. 2009 Mar;14(1):67-84.
4	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
5	N- and L-type calcium channel antagonist improves glomerular dynamics, reverses severe nephrosclerosis, and inhibits apoptosis and proliferation in an l-NAME/SHR model. J Hypertens. 2002 May;20(5):993-1000.
6	Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
7	Clinical pipeline report, company report or official report of Convergence Pharmaceuticals Ltd.
8	N,N-dialkyl-dipeptidylamines as novel N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Mar 22;9(6):907-12.
9	CNSB004 (Leconotide) causes antihyperalgesia without side effects when given intravenously: a comparison with ziconotide in a rat model of diabetic neuropathic pain. Pain Med. 2010 Feb;11(2):262-73.
10	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008159)
11	Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52.