Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHIS3M)

Drug Name

PRAX-330 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Epilepsy	8A60-8A68	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.6 (SCN8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NBI-921352	DMTTW9V	Epileptic encephalopathy	8A62	Phase 2	[2]
XEN901	DMRP9YF	Epilepsy	8A60-8A68	Phase 1	[3]
batrachotoxin	DMYH9SU	Discovery agent	N.A.	Investigative	[4]
veratridine	DMUF8JZ	Discovery agent	N.A.	Investigative	[4]
4,9-anhydro-tetrodotoxin	DMEKI1B	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated sodium channel alpha Nav1.6 (SCN8A)	TT54ERL	SCN8A_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Clinical pipeline report, company report or official report of Neurocrine Biosciences
3	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 583).
5	The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na(v1.6) voltage-dependent sodium channel. Am J Physiol Cell Physiol. 2007 Aug;293(2):C783-9.