Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHOJ0Z)

Drug Name

ISIS 298746 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting HIF1-alpha messenger RNA (HIF1A mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PT2385	DMCSN69	Recurrent glioblastoma	2A00.00	Phase 2	[2]
(5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol	DM15P2G	Discovery agent	N.A.	Investigative	[3]
ISIS 298697	DM0WH1L	Discovery agent	N.A.	Investigative	[1]
ISIS 298744	DM8VMQ4	Discovery agent	N.A.	Investigative	[1]
ISIS 298745	DM9YMPI	Discovery agent	N.A.	Investigative	[1]
ISIS 298743	DMD3NSQ	Discovery agent	N.A.	Investigative	[1]
ISIS 298702	DM4L7NE	Discovery agent	N.A.	Investigative	[1]
ISIS 298700	DM3DE98	Discovery agent	N.A.	Investigative	[1]
ISIS 175510	DMPAXR4	Discovery agent	N.A.	Investigative	[1]
ISIS 298699	DMB28JW	Discovery agent	N.A.	Investigative	[1]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HIF1-alpha messenger RNA (HIF1A mRNA)	TTSN6QU	HIF1A_HUMAN	Not Available	[1]

------------------------------------------------------------------------------------

References

1	US patent application no. 7,217,572, Modulation of HIF1.alpha. and HIF2.alpha. expression.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Synthesis of (aryloxyacetylamino)-isonicotinic/nicotinic acid analogues as potent hypoxia-inducible factor (HIF)-1alpha inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6305-10.