Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHPRWG)

Drug Name

Exjade Drug Info

Synonyms

Deferasirox

Indication

Disease Entry	ICD 11	Status	REF
Iron overload disease	5C64.10	Approved	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Iron (Fe)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etidronate Disodium	DMAWJIN	Osteoporosis	FB83.0	Approved	[3]
Deferiprone	DMS2M7O	Beta thalassemia	3A50.2	Approved	[4]
Deferoxamine Mesylate	DMTUKZH	Acute iron or aluminum toxicity	FB83.20	Approved	[3]
Soluble ferric pyrophosphate	DMLAYTP	Iron-deficiency anemia	3A00	Phase 3	[5]
SPD602	DMKJ9LU	Anemia	3A00-3A9Z	Phase 2	[6]
Monohydroxyethylrutoside	DMAQJHO	Cardiovascular disease	BA00-BE2Z	Phase 1	[7]
DpC	DM4ZDOE	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006).
2	Deferasirox : a review of its use in the management of transfusional chronic iron overload. Drugs. 2007;67(15):2211-30.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
5	A micronised, dispersible ferric pyrophosphate with high relative bioavailability in man. Br J Nutr. 2004 Jan;91(1):107-12.
6	ClinicalTrials.gov (NCT01604941) Pharmacokinetics of SSP-004184 in the Treatment of Chronic Iron Overload Requiring Chelation Therapy. U.S. National Institutes of Health.
7	Monohydroxyethylrutoside, a dose-dependent cardioprotective agent, does not affect the antitumor activity of doxorubicin. Clin Cancer Res. 1997 Oct;3(10):1747-54.
8	Anticancer Thiosemicarbazones: Chemical Properties, Interaction with Iron Metabolism, and Resistance Development. Antioxid Redox Signal. 2019 Mar 10;30(8):1062-1082.