Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHRCQI)

Drug Name

eFT226 Drug Info

Synonyms

Zotatifin; EFT226; UNII-2EWN8Z05CN; 2EWN8Z05CN; 2098191-53-6; EFT-226; Zotatifin [INN]; 4-((5aR,6S,7S,8R,8aS)-7-((Dimethylamino)methyl)-8,8a-dihydroxy-1,3-dimethoxy-6-phenyl-6,7,8,8a-tetrahydro-5ah-cyclopenta(4,5)furo(3,2-C)pyridin-5a-yl)benzonitrile; 4-((5aR,6S,7S,8R,8aS)-7-((Dimethylamino)methyl)-8,8a-dihydroxy-1,3-dimethoxy-6-phenyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[4,5]furo[3,2-c]pyridin-5a-yl)benzonitrile; Zotatifin [USAN]; Zotatifin (USAN/INN); CHEMBL4303782; SCHEMBL18864788; EX-A4623; NSC818001; NSC828584; WHO 10998; NSC-818001; NSC-828584; HY-112163; CS-0043584; D11837; Benzonitrile, 4-((5aR,6S,7S,8R,8aS)-7-((dimethylamino)methyl)-6,7,8,8a-tetrahydro-8,8a-dihydroxy-1,3-dimethoxy-6-phenyl-5ah-cyclopenta(4,5)furo(3,2-C)pyridin-5a-yl)-

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]

Cross-matching ID

PubChem CID: 129138801
CAS Number: CAS 2098191-53-6
TTD Drug ID: DMHRCQI

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting HUMAN eukaryotic initiation factor-4A (eIF4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Silvestrol	DM5JKNF	Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[3]
Hippuristanol	DM0PV2Y	T-cell leukaemia	2A90	Investigative	[4]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HUMAN eukaryotic initiation factor-4A (eIF4A)	TTIGYVZ	IF4A1_HUMAN; IF4A2_HUMAN; IF4A3_HUMAN	Inhibitor	[2]

------------------------------------------------------------------------------------

References

1	ClinicalTrials.gov (NCT04092673) Study of eFT226 in Subjects With Selected Advanced Solid Tumor Malignancies (Zotatifin). U.S. National Institutes of Health.
2	Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase. J Med Chem. 2020 Jun 11;63(11):5879-5955.
3	Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses. Antiviral Res. 2018 Feb;150:123-129.
4	Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia. Biochem Pharmacol. 2011 Mar 15;81(6):713-22.