Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHU742)

Drug Name

EPZ032597 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Preclinical	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Preclinical Drug(s)

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Drug(s) Targeting SET and MYND domain-containing protein 2 (SMYD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZ505	DMKQ20J	Solid tumour/cancer	2A00-2F9Z	Preclinical	[2]
LLY-507	DMNOE1M	Solid tumour/cancer	2A00-2F9Z	Preclinical	[3]
EPZ033294	DMDO6NZ	Solid tumour/cancer	2A00-2F9Z	Preclinical	[1]
A-893	DM8XHJG	Lung cancer	2C25.0	Preclinical	[4]
BAY 598	DMWH19X	Discovery agent	N.A.	Preclinical	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
SET and MYND domain-containing protein 2 (SMYD2)	TT7YJFO	SMYD2_HUMAN	Inhibitor	[1]

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References

1	Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286.
2	Structural basis of substrate methylation and inhibition of SMYD2. Structure. 2011 Sep 7;19(9):1262-73.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2714).
4	Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2. ACS Med Chem Lett. 2015 Apr 29;6(6):695-700.
5	Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. J Med Chem. 2016 May 26;59(10):4578-600.