Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHV58T)

• Drug Name: Peldesine Drug Info
• Cross-matching ID:
  PubChem CID: 135413525
  CAS Number: CAS 133432-71-0
  TTD Drug ID: DMHV58T

Molecule-Related Drug Atlas

Drug(s) Targeting Purine nucleoside phosphorylase (PNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BCX-3408	DMRSG31	Autoimmune diabetes	5A10	Phase 2	[2]
2'3'-Dideoxyinosine	DMZWNQF	N. A.	N. A.	Phase 2	[1]
Forodesine	DME2W4T	B-cell acute lymphoblastic leukaemia	2B33.3	Phase 1/2	[3]
Guanosine	DM4T5LH	N. A.	N. A.	Phase 1	[1]
CI-972	DM9ZBO0	Rheumatoid arthritis	FA20	Discontinued in Phase 1	[4]
7-tert-butyl-2, 3-dihydro-3, 3-dimethyl substituted dihydrofuran 30 (DHDMBF30)	DMSU06X	Discovery agent	N.A.	Investigative	[5]
Hypoxanthine	DMLSABI	Discovery agent	N.A.	Investigative	[1]
8-Iodo-Guanine	DM3K1EO	Discovery agent	N.A.	Investigative	[1]
8-Azaguanine	DM7VP90	Discovery agent	N.A.	Investigative	[1]
MT-Immucillin-H	DMK2FOX	Discovery agent	N.A.	Investigative	[6]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Purine nucleoside phosphorylase (PNP)	TTMCF1Y	PNPH_HUMAN	Inhibitor	[1]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] BCX-4208 (RO5092888), a Purine Nucleoside Phosphorylase (PNP) Inhibitor, Is a Novel, Potent Orally Active Anti-T-Cell and B-Cell Agent. 50th ASH Annual Meeting and Exposition. 2008.
• [3] Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 an... Blood. 2009 Aug 20;114(8):1563-75.
• [4] Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as potentially T-cell selective immunosuppressive agents. Description of 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d] pyrimidin-4-one. J Med Chem. 1992 May 1;35(9):1605-9.
• [5] Expression of human malaria parasite purine nucleoside phosphorylase in host enzyme-deficient erythrocyte culture. Enzyme characterization and identification of novel inhibitors. J Biol Chem. 1986 Sep 5;261(25):11667-73.
• [6] Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function. J Biol Chem. 2004 Apr 30;279(18):18103-6.