Details of the Drug-Related molecule(s) Interaction Atlas

Pyridine-carboximide derivative 2 Drug Info

PMID25470667-Compound-Figure5-6

Cross-matching ID

PubChem CID

56837993

TTD Drug ID

DMHXWZB

General Information of Drug (ID: DMHXWZB)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Diacylglycerol acyltransferase 1 (DGAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[2]
LCQ908	DMFLJHQ	Familial chylomicronemia syndrome	5C80	Phase 3	[3]
AZD7687	DMS9I6A	Diabetic complication	5A2Y	Phase 1	[4]
P-7435	DMNZQU5	Diabetic complication	5A2Y	Phase 1	[5]
PMID25470667-Compound-Figure4-1A	DMMVQW8	N. A.	N. A.	Patented	[1]
Azole derivative 7	DMVUJGI	N. A.	N. A.	Patented	[1]
Carbamide derivative 3	DM4ISCQ	N. A.	N. A.	Patented	[1]
T863	DMX41ZF	Discovery agent	N.A.	Patented	[1]
Benzamide derivative 19	DM5YNTM	N. A.	N. A.	Patented	[1]
Lactam derivative 5	DMX5FYZ	N. A.	N. A.	Patented	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Diacylglycerol acyltransferase 1 (DGAT1)	TTF8P9I	DGAT1_HUMAN	Inhibitor	[1]

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References

1	Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58.
2	In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Planta Med. 2004 Mar;70(3):258-60.
3	DGAT1 inhibitors as anti-obesity and anti-diabetic agents. Curr Opin Drug Discov Devel. 2010 Jul;13(4):489-96.
4	Clinical pipeline report, company report or official report of AstraZeneca (2011).
5	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033014)