Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHYQ8K)

Drug Name

Nerve growth factor Drug Info

Synonyms

Neuleze; Nerve growth factor (recombinant); RhNGF, Genentech; NGF-beta, Genentech; Nerve growth factor (recombinant), Genentech; Nerve growth factor, Mitsubishi/Dompe/Fidia

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Terminated	[1]

Cross-matching ID

TTD Drug ID: DMHYQ8K

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Nerve growth factor (NGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tanezumab	DMJKWMA	Cancer related pain	MG30	Phase 3	[3]
Fasinumab	DM5PRLA	Chronic low back pain	MG30.02	Phase 3	[3]
SAR164877	DMOJLCV	Pain	MG30-MG3Z	Phase 2/3	[4]
CERE-110	DMNW5I9	Alzheimer disease	8A20	Phase 2	[5]
CXB-909	DMUGMFN	Neurodegenerative disorder	8A20-8A23	Phase 1/2	[6]
ABT-110	DM1F50I	Chronic pain	MG30	Phase 1	[4]
NsG-0202	DM1ITDN	Alzheimer disease	8A20	Phase 1	[6]
MEDI-578	DMPW21Z	Pain	MG30-MG3Z	Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nerve growth factor (NGF)	TTDN3LF	NGF_HUMAN	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000658)
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Fate of novel painkiller mAbs hangs in balance.Nat Biotechnol.2011 Mar;29(3):173-4.
5	CERE-110, an adeno-associated virus-based gene delivery vector expressing human nerve growth factor for the treatment of Alzheimer's disease. Curr Opin Mol Ther. 2010 Apr;12(2):240-7.
6	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.