Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMI7CYZ)

Drug Name

Amiselimod Drug Info

Synonyms

Amiselimod; 942399-20-4; Amiselimod [INN]; Amiselimod free base; Amiselimod(MT-1303) free base; 942399-20-4 (free base); 358M5150LY; 2-amino-2-(4-(heptyloxy)-3-(trifluoromethyl)phenethyl)propane-1,3-diol; 2-Amino-2-(2-(4-heptyloxy-3-trifluoromethylphenyl)ethyl)propane-1,3-diol; 2-amino-2-[2-[4-heptoxy-3-(trifluoromethyl)phenyl]ethyl]propane-1,3-diol; 2-Amino-2-{2-[4-(heptyloxy)-3-(trifluoromethyl)phenyl]ethyl}propane-1,3-diol; UNII-358M5150LY; Amiselimod,MT1303; Amiselimod (USAN/INN); AMISELIMOD [USAN]; AMISELIMOD [WHO-DD]; MT-1303 FREE BASE; GTPL9319; SCHEMBL2463680; CHEMBL3707375; JVCPIJKPAKAIIP-UHFFFAOYSA-N; DTXSID301141402; BCP24738; EX-A1427; MT1303; AKOS032971355; Example 1 [US20090137530]; D10905; MT-1303; MT1303; MT 1303; Q27256444; 1,3-PROPANEDIOL, 2-AMINO-2-(2-(4-(HEPTYLOXY)-3-(TRIFLUOROMETHYL)PHENYL)ETHYL)-; 2-Amino-2-[2-[4-(heptyloxy)-3-(trifluoromethyl)phenyl]ethyl]-1,3-propanediol

Indication

Disease Entry	ICD 11	Status	REF
Ulcerative colitis	DD71	Phase 2	[1]

Cross-matching ID

PubChem CID: 16129483
TTD Drug ID: DMI7CYZ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Sphingosine-1-phosphate receptor 2 (S1PR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US8975409, Example 13	DMVB42P	N. A.	N. A.	Patented	[3]
SCHEMBL15295829	DMK0T9E	N. A.	N. A.	Patented	[4]
Jte 013	DMS3HNM	Discovery agent	N.A.	Patented	[4]
US8975409, Example 9(3)	DMJQOAE	N. A.	N. A.	Patented	[3]
Unii-R228S06soh	DMUHSAZ	N. A.	N. A.	Patented	[4]
US8975409, Comparative compound B	DM4S5DF	N. A.	N. A.	Patented	[3]
AUY954	DMVGIO5	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sphingosine-1-phosphate receptor 2 (S1PR2)	TTVSMOH	S1PR2_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT04857112) A Phase 2, Randomized, Double-Blinded, Placebo Controlled, Parallel Group Study Evaluating the Efficacy and Safety of Amiselimod (MT-1303) in Subjects With Mild to Moderate Ulcerative Colitis (UC). U.S.National Institutes of Health.
2	Amiselimod, a novel sphingosine 1-phosphate receptor-1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk. Br J Pharmacol. 2017 Jan;174(1):15-27.
3	Phenyl derivative. US8975409.
4	Sphingosine 1-phosphate receptor antagonists. US9663511.
5	A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol. 2006 Nov;13(11):1227-34.