Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMI7RPT)

• Drug Name: GalR3ant Drug Info
• Synonyms: GalR3ant; GTPL6127; SCHEMBL5362026; 3-(3,4-dichlorophenyl)imino-1-(6-methoxypyridin-3-yl)indol-2-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 9800980
  TTD Drug ID: DMI7RPT

Molecule-Related Drug Atlas

Drug(s) Targeting Galanin receptor (GAL-R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HT-2157	DM7C1AJ	Cognitive impairment	6D71	Phase 1/2	[3]
galmic	DML9DH8	Discovery agent	N.A.	Investigative	[4]
Sch 202596	DMRC4LE	Discovery agent	N.A.	Investigative	[5]
CYM2503	DM5NFEA	Discovery agent	N.A.	Investigative	[6]
(E)-3-(4-chlorophenylimino)indolin-2-one	DMPOYK2	Discovery agent	N.A.	Investigative	[7]
SNAP 398299	DMS1AFL	Discovery agent	N.A.	Investigative	[3]
(E)-3-(2,3-dichlorophenylimino)indolin-2-one	DM1LG27	Discovery agent	N.A.	Investigative	[7]
2,3-dihydro-1,4-dithiin-1,1,4,4-tetroxide	DMJB7W1	Discovery agent	N.A.	Investigative	[8]
dithiipin-1,1,4,4-tetroxide analogue 7	DMK0VFS	Discovery agent	N.A.	Investigative	[8]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Galanin receptor (GAL-R)	TTOPAY7	GALR1_HUMAN; GALR2_HUMAN; GALR3_HUMAN	Antagonist	[2]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6127).
• [2] Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes. Neuropeptides. 2005 Jun;39(3):165-7.
• [3] Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17489-94.
• [4] Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10470-5.
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 245).
• [6] GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15229-34.
• [7] 3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists. J Med Chem. 2006 Jun 29;49(13):3757-8.
• [8] 2,3-Dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides: small molecule non-peptide antagonists of the human galanin hGAL-1 receptor. Bioorg Med Chem. 2000 Jun;8(6):1383-91.