Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIJB68)

Drug Name

AC-625 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Discontinued in Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Amylin receptor (IAPPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DACRA 089	DM5TB76	Type 2 diabetes	5A11	Phase 1	[3]
Davalintide	DM9S3R8	Obesity	5B81	Discontinued in Phase 2	[4]
AC-253	DM704HO	Hypertension	BA00-BA04	Discontinued in Phase 1	[2]
AC-187	DM5IDAQ	Type-2 diabetes	5A11	Terminated	[5]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Amylin receptor (IAPPR)	TTAT87F	CALCR_HUMAN-RAMP1_HUMAN/RAMP2_HUMAN/RAMP3_HUMAN	Modulator	[2]

------------------------------------------------------------------------------------

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002980)
2	Biotechnology and Its Application in Pharmacy. Kulkarn. 2002. Page157.
3	A novel dual amylin and calcitonin receptor agonist, KBP-089, induces weight loss through a reduction in fat, but not lean mass, while improving food preference. Br J Pharmacol. 2017 Apr;174(7):591-602.
4	Davalintide (AC2307), a novel amylin-mimetic peptide: enhanced pharmacological properties over native amylin to reduce food intake and body weight. Int J Obes (Lond). 2010 Feb;34(2):385-95.
5	Antagonist of the amylin receptor blocks beta-amyloid toxicity in rat cholinergic basal forebrain neurons. J Neurosci. 2004 Jun 16;24(24):5579-84.