Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIK72F)

Drug Name

XR-5118 Drug Info

Synonyms

XR-5118; CHEMBL40180; CHEMBL544314; xr5118; SCHEMBL7359291; BDBM50104518; 3-[1-[5-(2-Dimethylamino-ethylsulfanyl)-thiophen-2-yl]-meth-(Z)-ylidene]-6-[1-phenyl-meth-(Z)-ylidene]-piperazine-2,5-dione

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Terminated	[1]

Cross-matching ID

PubChem CID: 9932718
TTD Drug ID: DMIK72F

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Endothelial plasminogen activator inhibitor (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
THR-18	DMBO021	Asthma	CA23	Phase 2	[3]
DIAPLASININ	DM6OJI1	Thrombosis	DB61-GB90	Phase 1	[4]
AR-HO29953XX	DM2PRHX	Discovery agent	N.A.	Investigative	[5]
Sideroxylonal C	DMSGNM1	Discovery agent	N.A.	Investigative	[6]
SIDEROXYLONAL B	DMDP7Y5	Discovery agent	N.A.	Investigative	[6]
SIDEROXYLONAL A	DMEIBTY	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Endothelial plasminogen activator inhibitor (SERPINE1)	TTTO43N	PAI1_HUMAN	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006898)
2	Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization. J Med Chem. 2004 Jul 1;47(14):3491-4.
3	THR-18, a 18-mer peptide derived from PAI-1, is neuroprotective and improves thrombolysis by tPA in rat stroke models. Neurol Res. 2011 Nov;33(9):983-90.
4	Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis. J Thromb Haemost. 2010 Jun;8(6):1333-9.
5	Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3514-8.
6	Sideroxylonal C, a new inhibitor of human plasminogen activator inhibitor type-1, from the flowers of Eucalyptus albens. J Nat Prod. 1999 Feb;62(2):324-6.