Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIKQ40)

Drug Name

AMG 076 Drug Info

Synonyms

AMG-076 free base; UNII-HX4T7JEV3D; HX4T7JEV3D; CHEMBL2032049; 693823-79-9; SCHEMBL2742722; DTXSID70219485; BDBM50383522; Cyclohexanecarboxylic acid, 1-(2-((4aR,11R,11aS)-1,3,4,4a,5,6,11,11a-octahydro-11-methyl-9-(trifluoromethyl)-2H-pyrido(4,3-b)carbazol-2-yl)ethyl)-; (4aR)-2-[2-(1-Carboxycyclohexyl)ethyl]-2,3,4,4abeta,5,6,11,11aalpha-octahydro-9-(trifluoromethyl)-11alpha-methyl-1H-pyrido[4,3-b]carbazole

Indication

Disease Entry	ICD 11	Status	REF
Obesity	5B81	Discontinued in Phase 1	[1]

Cross-matching ID

PubChem CID: 23642854
CAS Number: CAS 1001438-96-5
TTD Drug ID: DMIKQ40

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Melanin-concentrating hormone receptor 1 (MCHR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BMS-830216	DMCW71N	Obesity	5B81	Phase 1	[3]
AZD1979	DMQ1OX4	Obesity	5B81	Phase 1	[4]
PMID25522065-Compound-27	DMXN4KB	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-29	DMBNAK9	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-34	DMZDIRQ	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-39	DM5YMQH	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-40	DMCIQ01	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-11	DM410Z6	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-50	DMBWA0V	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-12	DMVKO9C	N. A.	N. A.	Patented	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Melanin-concentrating hormone receptor 1 (MCHR1)	TTX4RTB	MCHR1_HUMAN	Antagonist	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019931)
2	Stereoselective synthesis of a MCHr1 antagonist. J Org Chem. 2007 Dec 7;72(25):9648-55.
3	2011 Pipeline of Bristol-Myers Squibb.
4	Phase I clinical trial of AZD1979 for treating obesity. AstraZeneca plc
5	Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207.