Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIL37Z)

Drug Name
Losmapimod Drug Info
Synonyms
585543-15-3; GSK-AHAB; GW856553; GW856553X; UNII-F2DQF16BXE; F2DQF16BXE; GW-856553; 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide; Losmapimod [USAN:INN]; Losmapimod (GW856553X); GSKAHAB; GW 856553X; SB 856553; Losmapimod (USAN/INN); SCHEMBL1070401; GTPL7835; CHEMBL1088752; EX-A486; CHEBI:131167; KKYABQBFGDZVNQ-UHFFFAOYSA-N; MolPort-009-194-138; losmapimod pound> HMS3653G19; BCP09909; AOB87105; ZINC35793138; s7215; BDBM50418610; 2523AH; AKOS015994587
Indication
Disease Entry ICD 11 Status REF
Acute coronary syndrome BA41 Phase 3 [1]
Cross-matching ID
PubChem CID
11552706
ChEBI ID
CHEBI:131167
CAS Number
CAS 585543-15-3
TTD Drug ID
DMIL37Z

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Stress-activated protein kinase 2a (p38 alpha)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ozagrel DMIGKA1 Xerophthalmia 5B55.Y Phase 4 [2]
VX-702 DMKJDR6 Coronary artery disease BA80 Phase 2a [3]
VX-745 DMJAEG6 Alzheimer disease 8A20 Phase 2 [4]
Dilmapimod DMBYJ92 Acute lung injury NB32.3 Phase 2 [2]
PMID25991433-Compound-A1 DM89LF0 N. A. N. A. Patented [5]
PMID25991433-Compound-F2 DM37VIQ N. A. N. A. Patented [5]
PMID25991433-Compound-L2 DM58UO9 N. A. N. A. Patented [5]
PMID25991433-Compound-L3 DM3LWUR N. A. N. A. Patented [5]
PMID25991433-Compound-L1 DM2135Y N. A. N. A. Patented [5]
PMID25991433-Compound-O2 DMTROIQ N. A. N. A. Patented [5]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Stress-activated protein kinase 2a (p38 alpha) TTQBR95 MK14_HUMAN Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7835).
2 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
3 Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum. 2009 May;60(5):1232-41.
4 Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5.
5 c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72.