Details of the Drug-Related molecule(s) Interaction Atlas

US9598431, 2 Drug Info

SCHEMBL18609672; BDBM302859; US9598431, 2; (5S') inverted question markN-{[5-(Ethylsulfonyl)pyridine-2-yl]methyl}-5'-methyl-1-{(1S)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}-4',5'-dihydrospiro[piperidine-4,7'thieno[2,3-C]pyran]-2'-carboxamide

Cross-matching ID

PubChem CID

126669595

TTD Drug ID

DMILY1P

General Information of Drug (ID: DMILY1P)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting RAR-related orphan receptor-beta (RORB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9598431, 5	DMXGF56	N. A.	N. A.	Patented	[1]
US9598431, 1	DMRVQ5Z	N. A.	N. A.	Patented	[1]
all-trans-4-oxo-retinoic acid	DMM2R1N	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
RAR-related orphan receptor-beta (RORB)	TTGB2LZ	RORB_HUMAN	Inhibitor	[1]

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References

1	Compounds useful for inhibiting ROR-gamma-t. US9598431.
2	All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta. Nat Struct Biol. 2003 Oct;10(10):820-5.