Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMINZ4W)

• Drug Name: Tetrahydrobiopterin Drug Info
• Synonyms: tetrahydrobiopterin; 17528-72-2; 5,6,7,8-tetrahydrobiopterin; BRN 0544742; CHEBI:15372; 5,6,7,8-Tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone; L-erythro-2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3H)-pteridinon; (1R,2S)-(2-Amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)-1,2-propandiol; 5,6,7,8-erythro-tetrahydrobiopterin; 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one; Dapropterin; Phenoptin

Indication

Disease Entry	ICD 11	Status	REF
Malnutrition	5B50-5B71	Approved	[1]

• Therapeutic Class: Dietary supplement
• Cross-matching ID:
  PubChem CID: 135402045
  ChEBI ID: CHEBI:15372
  CAS Number: CAS 17528-72-2
  TTD Drug ID: DMINZ4W
  INTEDE Drug ID: DR2018

Molecule-Related Drug Atlas

Drug(s) Targeting Tyrosine 3-monooxygenase (TH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Phenylalanine	DMQXI9F	Malnutrition	5B50-5B71	Approved	[4]
L-Tyrosine	DM9O8DT	Malnutrition	5B50-5B71	Approved	[5]
Metyrosine	DMBYCU0	Pheochromocytoma	5A75	Approved	[6]
L1-79	DMLHPVW	Autism spectrum disorder	6A02	Phase 2	[7]
ProSavin	DMJ42E6	Parkinson disease	8A00.0	Phase 1/2	[8]
OXB-102	DMXF9DM	Parkinson disease	8A00.0	Phase 1/2	[9]
7,8-dihydrobiopterin	DMQU4XM	Discovery agent	N.A.	Investigative	[10]
alpha-propyldopacetamide	DMQKMX3	Discovery agent	N.A.	Investigative	[11]
Meta-Tyrosine	DM0748C	Discovery agent	N.A.	Investigative	[10]
3-iodotyrosine	DMNZMH6	Discovery agent	N.A.	Investigative	[11]

Drug(s) Metabolized By Tryptophan 5-hydroxylase 2 (TPH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[12]
Sapropterin	DM6GE21	Phenylketonuria	5C50.0	Investigative	[3]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosine 3-monooxygenase (TH)	TTUHP71	TY3H_HUMAN	Cofactor	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Tryptophan 5-hydroxylase 2 (TPH2) Main DME	DER6XYF	TPH2_HUMAN	Substrate	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5276).
• [2] Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. J Neural Transm Suppl. 2007;(72):113-20.
• [3] Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2. J Neurochem. 2007 Mar;100(6):1648-57.
• [4] Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. Curr Med Chem. 2007;14(4):455-67.
• [5] Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: comparison with that on tyrosine hydroxylase activity. Neurosci Lett. 2006 Jul 3;401(3):261-5.
• [6] Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulation. Hypertension. 1991 Jul;18(1):1-8.
• [7] Effect of L1-79 on Core Symptoms of Autism Spectrum Disorder: A Case Series. Clin Ther. 2019 Oct;41(10):1972-1981.
• [8] Clinical pipeline report, company report or official report of Oxford BioMedica.
• [9] Clinical pipeline report, company report or official report of Oxford BioMedica.
• [10] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [11] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1243).
• [12] Strain differences in basal and post-citalopram extracellular 5-HT in the mouse medial prefrontal cortex and dorsal hippocampus: relation with tryptophan hydroxylase-2 activity. J Neurochem. 2007 Nov;103(3):1111-20.