Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIOA9M)

Drug Name

Dehydropipernonaline Drug Info

Synonyms

Dehydropipernonaline; 107584-38-3; Dehydropipernoline; Piperidine, 1-[9-(1,3-benzodioxol-5-yl)-1-oxo-2,4,8-nonatrienyl]-, (E,E,E)-; Piperidine, 1-(9-(1,3-benzodioxol-5-yl)-1-oxo-2,4,8-nonatrienyl)-, (E,E,E)-; AC1O5SQM; CHEMBL483708; MolPort-039-101-180; KAYVDASZRFLFRZ-PQECNABGSA-N; N-(9-(3,4-Methylenedioxyphenyl)-2,4,8-nonatrienoyl)piperidine; ZINC14658239; 9-(3,4-Methylenedioxy)-2,4,8-nonatrienoic acid piperidide; (2E,4E,8E)-9-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylnona-2,4,8-trien-1-one; Piperidine, 1-[(2E,4E,8E)-9-(1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6439947
CAS Number: CAS 107584-38-3
TTD Drug ID: DMIOA9M

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting ICAM1 messenger RNA (ICAM1 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 1570	DMJ9G23	Lleum inflammation	1A40.0	Approved	[2]
Alicaforsen	DMQ509J	Lleum inflammation	1A40.0	Phase 3	[3]
INXC-ICAM1	DMODQW0	Transplant rejection	NE84	Terminated	[4]
A-286982	DM98VFW	Discovery agent	N.A.	Investigative	[5]
ISIS 11159	DM9V6FW	Discovery agent	N.A.	Investigative	[6]
ISIS 3224	DMAFEYG	Discovery agent	N.A.	Investigative	[6]
ISIS 1931	DMBMQNI	Discovery agent	N.A.	Investigative	[2]
PIPERROLEIN B	DMRVHWZ	Discovery agent	N.A.	Investigative	[1]
ISIS 2974	DM7K19L	Discovery agent	N.A.	Investigative	[2]
ISIS 3067	DMC9OL7	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ICAM1 messenger RNA (ICAM1 mRNA)	TTA1L39	ICAM1_HUMAN	Inhibitor	[1]

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References

1	Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4544-6.
2	US patent application no. 6,300,491, Oligonucleotide inhibition of cell adhesion.
3	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
4	ISIS 2302. INXC ICAM1, Oligo-TCS. Drugs R D. 1999 Jan;1(1):85-6.
5	Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5269-73.
6	US patent application no. 5,789,573, Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2.