Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIRG15)

Drug Name

MaC46/M87o Drug Info

Synonyms

HIV-1 infection gene therapy, Georg-Speyer-Haus

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus-1 infection	1C62	Phase 1/2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Human immunodeficiency virus Glycoprotein 41 (HIV gp41)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enfuvirtide	DM7YPM1	Human immunodeficiency virus infection	1C62	Approved	[3]
Sifuvirtide	DMMIWCE	Human immunodeficiency virus infection	1C62	Phase 3	[4]
ITV-1	DMCJX79	Human immunodeficiency virus infection	1C62	Phase 2	[5]
T-1249	DMB2NP8	Human immunodeficiency virus infection	1C62	Phase 1/2	[6]
Multi-envelope HIV vaccine	DMAGCHE	Human immunodeficiency virus infection	1C62	Phase 1	[7]
Combinectin	DMTLP1N	Human immunodeficiency virus infection	1C62	Phase 1	[8]
Gp41 HIV-1 vaccine	DM9JV80	Human immunodeficiency virus infection	1C62	Phase 1	[9]
------------------------------------------------------------------------------------


⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Glycoprotein 41 (HIV gp41)	TTG90S6	ENV_HV1H2	Modulator	[2]

------------------------------------------------------------------------------------

References

1	Creating genetic resistance to HIV. Curr Opin Immunol. 2012 Oct;24(5):625-32.
2	DOI: 10.1038/mt.sj.6300124
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Broad antiviral activity and crystal structure of HIV-1 fusion inhibitor sifuvirtide.J Biol Chem.2012 Feb 24;287(9):6788-96.
5	Clinical pipeline report, company report or official report of Immunotech Laboratories.
6	HIV entry inhibitors in clinical development. Curr Opin Pharmacol. 2002 Oct;2(5):523-8.
7	An assessment of the role of chimpanzees in AIDS vaccine research. Altern Lab Anim. 2008 Sep;36(4):381-428.
8	Clinical pipeline report, company report or official report of ViiV Healthcare.
9	Phase 1 safety and immunogenicity evaluation of ADVAX, a multigenic, DNA-based clade C/B' HIV-1 candidate vaccine. PLoS One. 2010 Jan 25;5(1):e8617.