Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIRX3Z)

Drug Name

BM-212 Drug Info

Synonyms

BM-212; BM212; UNII-U9HSU4GZWL; 146204-42-4; U9HSU4GZWL; 1-{[1,5-Bis(4-chlorophenyl)-2-methylpyrrol-3-yl]methyl}-4-methylpiperazine; 1-[[1,5-bis(4-chlorophenyl)-2-methylpyrrol-3-yl]methyl]-4-methylpiperazine; BM 212; AC1L9VRH; CHEMBL321077; SCHEMBL1452627; BCP24821; ZINC22445591; AKOS032944899; CS-5953; Piperazine, 1-((1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methyl-; HY-100725

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Phase 1	[1]

Cross-matching ID

PubChem CID: 456926
CAS Number: CAS 146204-42-4
TTD Drug ID: DMIRX3Z

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Mycobacterium Membrane protein mmpL3 (MycB mmpL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SQ-109	DMWK9BX	Bacterial infection	1A00-1C4Z	Phase 2	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mycobacterium Membrane protein mmpL3 (MycB mmpL3)	TTTLB3R	MMPL3_MYCTU	Modulator	[1]

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References

1	MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrob Agents Chemother. 2012 Jan;56(1):324-31.
2	SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2012 Apr;56(4):1797-809.