Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJ9RN8)

Drug Name

SAR-339658 Drug Info

Synonyms

CHR-1103; GBR-500; TMC-2003; Integrin antibody (inflammation), Chromos; Integrin antibody (inflammation), Targeted Molecules Corp; Integrin antibody (multiple sclerosis), Chromos; Integrin antibody (multiple sclerosis), Glenmark; CD49b antagonist (inflammation/multiple sclerosis), Glenmark

Indication

Disease Entry	ICD 11	Status	REF
Inflammatory bowel disease	DD72	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMJ9RN8

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Integrin alpha-2/beta-1 (ITGA2/B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valetizumab	DMIKH67	Multiple sclerosis	8A40	Phase 2	[3]
Vatelizumab	DM3V7QO	Multiple sclerosis	8A40	Phase 2	[3]
Evatak	DMNMEAW	Solid tumour/cancer	2A00-2F9Z	Investigative	[2]
TCI15	DM06DI1	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Integrin alpha-2/beta-1 (ITGA2/B1)	TTMSB0A	ITA2_HUMAN-ITB1_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT01659138) Efficacy and Safety of SAR339658 in Patients With Moderate to Severe Ulcerative Colitis. U.S. National Institutes of Health.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2578).
3	Sulfonamide inhibitors of alpha2beta1 integrin reveal the essential role of collagen receptors in in vivo models of inflammation. Pharmacol Res Perspect. 2015 June; 3(3): e00146.
4	Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism. Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):719-24.