General Information of Drug (ID: DMJA5Y4)

Drug Name
2-(4-benzoylpiperazin-1-yl)thiazole-5-carboxamide Drug Info
Synonyms CHEMBL568131; 2-(4-benzoylpiperazin-1-yl)thiazole-5-carboxamide
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
45487374
TTD Drug ID
DMJA5Y4

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug(s) Targeting Acyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isoxyl DMJL10P Bacterial infection 1A00-1C4Z Approved [2]
Aramchol DMDLGRO Lipid metabolism disorder 5C52.Z Phase 2/3 [3]
MK-8245 DMG6KXB Type-2 diabetes 5A11 Phase 2 [4]
Sterculic acid DM1PMR3 Discovery agent N.A. Investigative [5]
ISIS 147919 DMTE3FJ Discovery agent N.A. Investigative [6]
MF-152 DMBLUSA Discovery agent N.A. Investigative [7]
CVT-12012 DMOCKMZ Diabetic complication 5A2Y Investigative [8]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acyl-CoA desaturase (SCD) TT6RIOV ACOD_HUMAN Inhibitor [1]

References

1 Thiazole analog as stearoyl-CoA desaturase 1 inhibitor. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5214-7.
2 Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92.
3 The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2014 Dec;12(12):2085-91.e1.
4 Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. J Med Chem. 2011 Jul 28;54(14):5082-96.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
6 US patent application no. 7,132,529, Antisense modulation of stearoyl-CoA desaturase expression.
7 SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1593-7.
8 Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4070-4.