General Information of Drug (ID: DMJB7W1)

Drug Name
2,3-dihydro-1,4-dithiin-1,1,4,4-tetroxide Drug Info
Synonyms 2,3-dihydro-1,4-dithiin-1,1,4,4-tetroxide; GTPL3486; SCHEMBL10948770; 5,6-Dihydro-1,4-dithiin-1,1,4,4-tetraoxide; 2,3-dihydro-1,4-dithiine 1,1,4,4-tetraoxide
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
20549618
TTD Drug ID
DMJB7W1

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Drug(s) Targeting Galanin receptor (GAL-R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
HT-2157 DM7C1AJ Cognitive impairment 6D71 Phase 1/2 [3]
galmic DML9DH8 Discovery agent N.A. Investigative [4]
Sch 202596 DMRC4LE Discovery agent N.A. Investigative [5]
GalR3ant DMI7RPT Discovery agent N.A. Investigative [6]
CYM2503 DM5NFEA Discovery agent N.A. Investigative [7]
(E)-3-(4-chlorophenylimino)indolin-2-one DMPOYK2 Discovery agent N.A. Investigative [8]
SNAP 398299 DMS1AFL Discovery agent N.A. Investigative [3]
(E)-3-(2,3-dichlorophenylimino)indolin-2-one DM1LG27 Discovery agent N.A. Investigative [8]
dithiipin-1,1,4,4-tetroxide analogue 7 DMK0VFS Discovery agent N.A. Investigative [2]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Galanin receptor (GAL-R) TTOPAY7 GALR1_HUMAN; GALR2_HUMAN; GALR3_HUMAN Antagonist [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3486).
2 2,3-Dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides: small molecule non-peptide antagonists of the human galanin hGAL-1 receptor. Bioorg Med Chem. 2000 Jun;8(6):1383-91.
3 Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17489-94.
4 Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10470-5.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 245).
6 Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes. Neuropeptides. 2005 Jun;39(3):165-7.
7 GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15229-34.
8 3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists. J Med Chem. 2006 Jun 29;49(13):3757-8.