Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJD479)

Drug Name

THPO Drug Info

Synonyms

THPO; 53602-00-9; 4,5,6,7-Tetrahydroisoxazolo(4,5-c)pyridin-3-ol; 4,5,6,7-Tetrahydroisoxazolo[4,5-c]pyridin-3-ol; CHEMBL150830; Isoxazolo(4,5-d)pyridin-3(2H)-one, 4,5,6,7-tetrahydro-; 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3(2H)-one; AC1Q6C1M; SCHEMBL455554; GTPL4727; AC1L1C13; isoxazolo[4,5-c]pyridin-3-ol, 4,5,6,7-tetrahydro-; CTK4J8459; DTXSID90201822; SXXLKZCNJHJYFL-UHFFFAOYSA-N; FCH907083; BDBM50226145; ZINC13803345; AKOS022718554; AKOS006371191; API0009745; DA-05117; LS-183574; FT-0754243

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1695
CAS Number: CAS 53602-00-9
TTD Drug ID: DMJD479

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Gamma-aminobutyric acid uptake (GABAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tiagabine	DMKSQG0	Epilepsy	8A60-8A68	Approved	[3]
NNC 05-2045	DMPZ1EC	N. A.	N. A.	Terminated	[4]
(R)-nipecotic acid	DMWGB40	Discovery agent	N.A.	Investigative	[5]
4-substituted 2,4-dioxobutanoic acids	DMELGKY	Discovery agent	N.A.	Investigative	[5]
NNC 711	DM0C8N3	Discovery agent	N.A.	Investigative	[6]
Cis-4-hydroxynipecotic acid	DMX07BG	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gamma-aminobutyric acid uptake (GABAU)	TTV9MQG	NOUNIPROTAC	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4727).
2	Anticonvulsant activity of intracerebroventricularly administered glial GABA uptake inhibitors and other GABAmimetics in chemical seizure models. Epilepsy Res. 1989 Jul-Aug;4(1):34-41.
3	Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
4	GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology. 2000 Sep;39(12):2399-407.
5	GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects. Curr Pharm Des. 2000 Aug;6(12):1193-209.
6	Effects of NNC 711, a GABA uptake inhibitor, on pentylenetetrazol-induced seizures in developing and adult rats. Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep;358(3):334-41.
7	GABA uptake inhibitors. Synthesis and effects on audiogenic seizures of ester prodrugs of nipecotic acid, guvacine and cis-4-hydroxynipecotic acid. Drug Des Deliv. 1987 Sep;2(1):9-21.