Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJGWZ7)

Drug Name

Eculizumab Drug Info

Synonyms

Eculizumab (intravitreal, AMD); Eculizumab (intravitreal, AMD), Alexion; Eculizumab (intravitreal, age-related macular degeneration), Alexion

Indication

Disease Entry	ICD 11	Status	REF
Age-related macular degeneration	9B75.0	Approved	[1]
Neuromyelitis optica	8A43	Approved	[2]
Paroxysmal nocturnal haemoglobinuria	3A21.0	Approved	[3]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[4]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting HUMAN complement C5 protein (C5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ravulizumab	DMSWNJF	Paroxysmal nocturnal haemoglobinuria	3A21.0	Approved	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6884).
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3	Paroxysmal nocturnal haemoglobinuria. Nat Rev Dis Primers. 2017 May 18;3:17028.
4	ClinicalTrials.gov (NCT04346797) CORIMUNO19-ECU: Trial Evaluating Efficacy and Safety of Eculizumab (Soliris) in Patients With COVID-19 Infection, Nested in the CORIMUNO-19 Cohort
5	Complement as a target in COVID-19 Nat Rev Immunol. 2020 Apr 23.