Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJL09Z)

Drug Name

Aficamten Drug Info

Synonyms

Aficamten; 2364554-48-1; Aficamten [INN]; Aficamten [USAN]; CK-3773274; B1I77MH6K1; Aficamten [USAN:INN]; UNII-B1I77MH6K1; CHEMBL4847050; WHO 11544; 1H-Pyrazole-4-carboxamide, N-((1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-1-methyl-; N-((1R)-5-(5-Ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)- 1-methyl-1H-pyrazole-4-carboxamide; N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methylpyrazole-4-carboxamide; SCHEMBL21179170; GTPL11524; EX-A5344; BDBM50575173; CK-274; AKOS040759755; MS-25122; CK3773274; HY-139465; CK-3773274;CK-274; CS-0202223; (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-1-methyl-1H-pyrazole-4-carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Hypertrophic cardiomyopathy	BC43.1	Phase 3	[1]

Cross-matching ID

PubChem CID: 139331495
TTD Drug ID: DMJL09Z

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Cardiac myosin (MYBPC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Omecamtiv mecarbil	DM624TW	Heart failure	BD10-BD13	Phase 3	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cardiac myosin (MYBPC3)	TT9WOBN	MYPC3_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT05767346) A Phase 3, Multi-center, Randomized, Double-blind Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy. U.S.National Institutes of Health.
2	Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy. J Med Chem. 2021 Oct 14;64(19):14142-14152.
3	CK-1827452, a sarcomere-directed cardiac myosin activator for acute and chronic heart disease. IDrugs. 2009 Apr;12(4):243-51.