Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJLRC7)

Drug Name

XR-3005 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Colorectal cancer	2B91.Z	Terminated	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting CAAX farnesyltransferase beta (FNTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-745631	DM4UP7R	Solid tumour/cancer	2A00-2F9Z	Terminated	[3]
ABT-839	DM4UN9A	Non-small-cell lung cancer	2C25.Y	Terminated	[4]
MANUMYCIN A	DM1SWOY	N. A.	N. A.	Terminated	[5]
SCH-44342	DMUL4VX	N. A.	N. A.	Terminated	[3]
RPR-113829	DMJ63GW	N. A.	N. A.	Terminated	[6]
RPR-114334	DMAIJT6	N. A.	N. A.	Terminated	[6]
L-731735	DM1XBKC	Solid tumour/cancer	2A00-2F9Z	Terminated	[3]
FUSIDIENOL	DMI1Y92	N. A.	N. A.	Terminated	[7]
ABT-100	DMPFLS5	Solid tumour/cancer	2A00-2F9Z	Terminated	[8]
B-956	DM1IO9X	Solid tumour/cancer	2A00-2F9Z	Terminated	[9]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
CAAX farnesyltransferase beta (FNTB)	TT7WZIJ	FNTB_HUMAN	Modulator	[2]

------------------------------------------------------------------------------------

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005580)
2	US patent application no. 2005,0227,929, Combination therapy comprising a cox-2 inhibitor and an antineoplastic agent.
3	Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90.
4	Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase. Bioorg Med Chem Lett. 2005 Jan 3;15(1):153-8.
5	A novel metal-chelating inhibitor of protein farnesyltransferase. Bioorg Med Chem Lett. 2003 May 5;13(9):1523-6.
6	Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase. J Med Chem. 1997 Jun 6;40(12):1763-7.
7	Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking. J Med Chem. 2002 Mar 28;45(7):1460-5.
8	Potent farnesyltransferase inhibitor ABT-100 abrogates acute allograft rejection. J Heart Lung Transplant. 2005 Sep;24(9):1403-9.
9	Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956. Cancer Res. 1995 Nov 15;55(22):5310-4.