Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJM9LZ)

Drug Name

LB80380 Drug Info

Synonyms

LB80380; UNII-S9I9P4J8IU; LB 80380; S9I9P4J8IU; LB-80380; 441785-26-8; PMCDG dipivoxil; AC1O59EP; SCHEMBL4270816; CHEMBL1652128; ANA-380; DTXSID90196062; J3.616.617G; [[1-[(2-aminopurin-9-yl)methyl]cyclopropoxy]methyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate; [({[(2-Aminopurin-9-yl)methyl]cyclopropoxy}methyl)[(2,2-dimethylpropanoyloxy)methoxy]carbonyloxy]methyl 2,2-dimethylpropanoate; 872968-04-2

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis B virus infection	1E51.0	Phase 2b	[1]

Cross-matching ID

PubChem CID: 6480442
CAS Number: CAS 441785-26-8
TTD Drug ID: DMJM9LZ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Hepatitis B virus Reverse transcriptase (HBV RT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[2]
Clevudine	DMR21Q3	Hepatitis B	1E51	Phase 3	[3]
Pradefovir	DM1O0DV	Hepatitis virus infection	1E50-1E51	Phase 2	[4]
MIV-210	DM2NF6X	Hepatitis B virus infection	1E51.0	Phase 2	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hepatitis B virus Reverse transcriptase (HBV RT)	TTS5K1M	DPOL_HBVA3	Inhibitor	[1]

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References

1	2011 Pipeline of LG Life Sciences.
2	Effect of hepatitis B virus reverse transcriptase variations on entecavir treatment response. J Infect Dis. 2014 Sep 1;210(5):701-7.
3	2011 Pipeline of Bukwang.
4	DOI: 10.1128/AAC.01566-05
5	Emerging antivirals for the treatment of hepatitis B