General Information of Drug (ID: DMJN8UW)

Drug Name
EQ121 Drug Info
Indication
Disease Entry ICD 11 Status REF
Rheumatoid arthritis FA20 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMJN8UW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting Janus kinase 1 (JAK-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Baricitinib DM4ONW5 Rheumatoid arthritis FA20 Approved [2]
Ruxolitinib DM7Q98D Essential thrombocythemia 3B63.1Z Approved [3]
Upadacitinib DM32B5U Rheumatoid arthritis FA20 Approved [4]
ASP-015K DMZ1UOI Psoriasis vulgaris EA90 Phase 3 [5]
SHR0302 DMUL8ZT Ulcerative colitis DD71 Phase 3 [6]
Cerdulatinib DMSCR2H B-cell lymphoma 2A86 Phase 2 [7]
CTP-543 DM3SYOK Alopecia ED70 Phase 2 [8]
INCB039110 DMD9RV3 Malignant neoplasm 2A00-2F9Z Phase 2 [5]
PF-06700841 DMMGSFV Asthma CA23 Phase 2 [7]
ATI-501 DMTY6OF Alopecia ED70 Phase 2 [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Janus kinase 1 (JAK-1) TT6DM01 JAK1_HUMAN Inhibitor [1]

References

1 Clinical pipeline report, company report or official report of EQRx
2 Selective JAK inhibitors in development for rheumatoid arthritis. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77.
3 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2047).
6 Efficacy and Safety of SHR0302, a Highly Selective Janus Kinase 1 Inhibitor, in Patients with Moderate to Severe Atopic Dermatitis: A Phase II Randomized Clinical Trial. Am J Clin Dermatol. 2021 Nov;22(6):877-889.
7 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9 Clinical pipeline report, company report or official report of Aclaris Therapeutics.