General Information of Drug (ID: DMJNQ5G)

Drug Name
ATC0065 Drug Info
Synonyms ATC-0065; ATC 0065
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11238212
CAS Number
CAS 509145-82-8
TTD Drug ID
DMJNQ5G

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BMS-830216 DMCW71N Obesity 5B81 Phase 1 [3]
AZD1979 DMQ1OX4 Obesity 5B81 Phase 1 [4]
PMID25522065-Compound-27 DMXN4KB N. A. N. A. Patented [5]
PMID25522065-Compound-29 DMBNAK9 N. A. N. A. Patented [5]
PMID25522065-Compound-34 DMZDIRQ N. A. N. A. Patented [5]
PMID25522065-Compound-39 DM5YMQH N. A. N. A. Patented [5]
PMID25522065-Compound-40 DMCIQ01 N. A. N. A. Patented [5]
PMID25522065-Compound-11 DM410Z6 N. A. N. A. Patented [5]
PMID25522065-Compound-50 DMBWA0V N. A. N. A. Patented [5]
PMID25522065-Compound-12 DMVKO9C N. A. N. A. Patented [5]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
melanin-concentrating hormone DMY57L0 Discovery agent N.A. Investigative [6]
PMID22123324C38 DMZ5BHX Discovery agent N.A. Investigative [7]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Melanin-concentrating hormone receptor 1 (MCHR1) TTX4RTB MCHR1_HUMAN Antagonist [2]
Melanin-concentrating hormone receptor 2 (MCHR2) TTS17MG MCHR2_HUMAN Antagonist [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1304).
2 Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagoni... J Pharmacol Exp Ther. 2005 May;313(2):831-9.
3 2011 Pipeline of Bristol-Myers Squibb.
4 Phase I clinical trial of AZD1979 for treating obesity. AstraZeneca plc
5 Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207.
6 Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7564-9.
7 Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2. Bioorg Med Chem Lett. 2012 Jan 1;22(1):363-6.