Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJU39N)

Drug Name

Endovion Drug Info

Synonyms

Angiogenesis inhibitor, NeuroSearch; Chloride channel antagonist, NeuroSearch; NS-1652; NS-3728

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Terminated	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Chloride channel unspecific (ClC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TM-601	DMKV5UM	Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
Lancovutide	DM7MBV6	Chronic obstructive pulmonary disease	CA22	Phase 2	[4]
131I-TM-601	DMTIED1	Glioma	2A00.0	Phase 2	[5]
BLZ-100	DMFKA4G	Glioma	2A00.0	Phase 1/2	[6]
GR-213487	DMCXLIK	Cystic fibrosis	CA25	Discontinued in Phase 2	[7]
TgAAV-CFTR	DMQSNV8	Cystic fibrosis	CA25	Discontinued in Phase 2	[8]
------------------------------------------------------------------------------------


⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Chloride channel unspecific (ClC)	TTCYAXN	NOUNIPROTAC	Antagonist	[2]

------------------------------------------------------------------------------------

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4273).
2	Inhibition of the endogenous volume-regulated anion channel (VRAC) in HEK293 cells by acidic di-aryl-ureas. J Membr Biol. 2003 Nov 15;196(2):83-94.
3	NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels. Biochemistry. 1995 Jan 10;34(1):13-21.
4	Airway-rehydrating agents for the treatment of cystic fibrosis: past, present, and future. Ann Pharmacother. 2011 Jan;45(1):49-59.
5	Imaging glioma extent with 131I-TM-601. J Nucl Med. 2005 Apr;46(4):580-6.
6	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
7	EP patent application no. 1336602, Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases.
8	Novel molecular approaches to cystic fibrosis gene therapy. Biochem J. 2005 April 1; 387(Pt 1): 1-15.