Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJUJT2)

Drug Name

ION904 Drug Info

Synonyms

tonlamarsen

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Angiotensinogen messenger RNA (AGT mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zilebesiran	DMS2QRT	Hypertension	BA00-BA04	Phase 2	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensinogen messenger RNA (AGT mRNA)	TT866WZ	ANGT_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT05314439) A Double-Blind, Placebo-Controlled, Phase 2 Study to Assess the Safety, Tolerability and Efficacy of Monthly Subcutaneous Administration of ION904 in Patients With Uncontrolled Hypertension. U.S.National Institutes of Health.
2	Antisense oligonucleotides targeting hepatic angiotensinogen reduce atherosclerosis and liver steatosis in hypercholesterolemic mice. Glob Transl Med. 2023;2(1):288.
3	ClinicalTrials.gov (NCT05103332) A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Zilebesiran Used as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication. U.S.National Institutes of Health.